• Another interesting finding regarding substrate selectivity

  2020-03-31

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty Nuclear/Cytosol Fractionation Kit at the sn-2 position [57,119], raising the possibility that iP

• This study has some limitations First

  2020-03-31

  

  This study has some limitations. First, the immunoblot analyses performed in the present study did not test for whole retinal antigens. Therefore, we could not exclude the possibility that the clinical features of our cases were caused by the activity of other antiretinal antibodies, although the sa

• br Funding br Disclosure of interest

  2020-03-31

  

  Funding Disclosure of interest Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic disease characterized by extensive deposits of the extracellular matrix (ECM) that can impair the architecture and function of the lungs (Cavazza et al., 2010). Imbalance between the prolife

• br Introduction The protein Epidermal Growth Factor Receptor

  2020-03-31

  

  Introduction The protein Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) play important role in non small-cell lung carcinoma (NSCLC) and vital therapeutic progress withinin the treatment of this ailment has revamped the past ten years through the exploitation of this insight (Mok et a

• The yeast Rad p radiation

  2020-03-31

  

  The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit

• meclofenamate A range of inhibitors were therefore synthesiz

  2020-03-31

  

  A range of inhibitors were therefore synthesized containing either carboxylic meclofenamate or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respectively (). Analy

• br Other Alterations in Triglyceride Metabolism in DGAT Defi

  2020-03-31

  

  Other Alterations in Triglyceride Metabolism in DGAT-Deficient Mice Consistent with the enzyme\'s ubiquitous expression pattern, DGAT deficiency also altered triglyceride metabolism in other tissues. For example, postpartum Dgat−/− female mice were unable to nurse their young owing to an absence

• In the present study cells were exposed

  2020-03-30

  

  In the present study, cells were exposed to a low level of arsenite and a low cytotoxic concentration of BaP. Thus, γ-H2AX loss correlated with repair of DNA damage in cells co-exposed to arsenite and BaP. These results show that arsenite inhibits repair of BaP-induced DNA damage. In a previous stud

• Our previous high throughput screening HTS campaign using au

  2020-03-30

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based dna staining assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21], [22],

• br Structural and biochemical features of

  2020-03-30

  

  Structural and biochemical features of pol X family polymerases The X-family DNA polymerase (polX) is specialized in DNA repair. This family is composed of four different DNA polymerases: pol β, pol λ, pol μ and TdT. Only three members of the polX family possess an N-terminal BRCT (BRCA1 carboxy-

• br Acknowledgements This work was supported

  2020-03-30

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• Moreover a ligand for fusin

  2020-03-30

  

  Moreover, a ligand for fusin has recently been found: the lymphocyte chemoattractant stromal-derived factor-1 (SDF-1) binds to CHO Kif15-IN-1 synthesis transfected with fusin and promotes secondary messenger production (Bleul et al., 1996; Oberlin et al., 1996). A new name, CXCR-4, has been proposed

• br Conclusion br Acknowledgments This work was supported by

  2020-03-27

  

  Conclusion Acknowledgments This work was supported by Progetto PON - “Ricerca e Competitività 2007–2013” - PON01_01802: “Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redox-sensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e lo

• XMD17-109 In conclusion we for the first

  2020-03-27

  

  In conclusion, we for the first time demonstrated the enzyme activity and immunoprotective traits of bioactive recombinant SjCE-2b, which was successfully recovered by protein refolding from inclusion bodies. The results address two essential questions that were undocumented in previous investigatio

• br Fragment based drug discovery FBDD

  2020-03-27

  

  Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical GSK 2837808A space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency. It

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