• The Met allele presents lower thermostability resulting in

  2020-08-03

  

  The Met allele presents lower thermostability resulting in lower COMT activity at physiological temperature (Chen et al., 2004). Due to its degradation rate that is ⅓ to ¼ slower, DA availability at the synaptic clefts is increased. On the other hand, homozygous subjects for the Val allele show a hi

• br The EWSR gene is a member of the TET

  2020-08-03

  

  The EWSR1 gene is a member of the TET (translocated in liposarcoma [TLS]/fused in sarcoma [FUS], EWSR1, TATA-binding protein-associated factor 15 [TAF15]) family, a group of genes involved in several translocation-associated sarcomas.35, 36, 37, 38, 39 EWSR1, sited between base-pairs 29,663,998 an

• br An abundant body of work dating

  2020-08-03

  

  An abundant body of work dating back from the 90\'s has documented the involvement of sPLA2-V in AA mobilization and attendant eicosanoid production [131]. In general terms, sPLA2-V acts by amplifying the action of cPLA2α, which is the key enzyme in the process, via activity-dependent or -independ

• Alternation of joints by mechanical stress produces microcra

  2020-08-03

  

  Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides Coumarin receptor for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in the injured cartilage releases transforming growth fac

• MEN Montelukast Zafirlukast and Pranlukast

  2020-07-31

  

  MEN91507, Montelukast, Zafirlukast, and Pranlukast antagonized leukotriene D4-induced bronchoconstriction in guinea-pigs, following both intravenous and oral administration. When administered intravenously, MEN91507 was the most potent amongst the CysLT1 receptor antagonists tested, since the ED50s

• br ET Antagonist for the Future

  2020-07-31

  

  ET Antagonist for the Future: Macitentan and Atresentan Macitentan is an insurmountable antagonist, resulting from structure-activity studies to improve the efficacy and tolerability of bosentan, and gained approval in the United States in 2013 for the treatment of PAH. Actelion describes the com

• A striking finding was that hypertension or diabetes increas

  2020-07-31

  

  A striking finding was that hypertension or diabetes increased ETRA, ETRB, ET-1 and ET-2 SCH 58261 in retina and RPE/choroid. These levels were not further increased by the combination of hypertension and diabetes indicating that either condition may have induced maximal stimulation of the ET system

• The number of leukocytes in the

  2020-07-31

  

  The number of leukocytes in the bronchoalveolar lavage and the total number of macrophages and neutrophils in the alveolar space of the PPE 64d group was higher than that in the control group. Jiang et al. [29] investigated the role of the serotonin (5-HT or 5-HTT) transporter and the effect of simv

• Elastin is a highly elastic protein

  2020-07-31

  

  Elastin is a highly elastic protein found in connective tissues including skin, lung, and arteries and helps in maintaining tissue configuration after stretch or recoil (Daamen et al., 2007, Debelle and Alix, 1999). Overexposure to UV irradiation and oxidative damage up regulate the expression of el

• PF-06447475 PRRSV is a single stranded positive

  2020-07-31

  

  PRRSV is a single-stranded, positive-sense enveloped RNA virus in the family Arteriviridae of the order Nidovirales (Meng et al., 1994, 1996). The PRRSV PF-06447475 is approximately 15 kb in length and contains eleven known open reading frames (ORFs) (Snijder et al., 2013). The 3′ end of the genome

• The results revealed VMH lesions downregulated some genes

  2020-07-31

  

  The results revealed VMH lesions downregulated some genes that are involved in positive regulation of immune system process, positive regulation of immune response, immune response, leukocyte activation, activation of immune response, chemokine receptor binding, chemokine activity, lymphocyte activa

• PBMC derived macrophages not only express EBI but

  2020-07-31

  

  PBMC-derived macrophages not only express EBI2 but also have the ability to respond to their natural agonist 7α,25-OHC by activating downstream signal transduction pathways. In line with previous findings, our data confirm that receptor stimulation induces calcium mobilization which can be blocked b

• br Ubiquitin Capture by the Mobile

  2020-07-31

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the acpt correlates with processivity of thei

• The interface between the E ligase

  2020-07-31

  

  The interface between the E3 ligase and the E2 enzyme can vary, and ZNF451 and SP-RING ligases stabilize this interaction via noncovalent binding to a scaffold SUMO (SUMOB) on the backside of the E2 (Cappadocia et al., 2015; Eisenhardt et al., 2015; Streich & Lima, 2016). By contrast, RanBP2 does no

• As CP is a crucial

  2020-07-31

  

  As CP110 is a crucial player in centriole duplication, it is intriguing to ask whether centriole duplication would also be affected in the absence of the CP110-stabilizing effects of USP33. Li et al.[4] found that USP33 depletion did not inhibit normal centriole duplication through loss of centriole

16057 records 831/1071 page Previous Next First page 上5页 831832833834835 下5页 Last page