• br Materials and methods br Results Overexpression of KLF

  2021-08-31

  

  Materials and methods Results Overexpression of KLF2 increased the cell viability and reduced the LDH leakage rate and O2•− and ONOO− generation in H/R HUVEC model. To evaluate the effect of KLF2 on H/R HUVEC injury, KLF2 was overexpressed in HUVECs. Cell viability and extracellular LDH level

• br Conflict of Interest br Statement of Authorship br

  2021-08-31

  

  Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho

• Similarly synthetic analogs of Alogliptin by replacing the

  2021-08-30

  

  Similarly synthetic analogs of Alogliptin by replacing the cyanobenzyl group with the butynyl group have been synthesized and tested as selective DPP-4 inhibitors [7], [8]. Additionally, quinazolines [9], [10], pyridopyrimidinediones [11], pyrazolopyrimidinones [12] and pyrimidines [13] as DPP-IV in

• Introduction The Discoidin Domain Receptors DDRs

  2021-08-30

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• Recent studies have shown arsenic

  2021-08-30

  

  Recent studies have shown arsenic could cause autophagic cell death in malignant cells, including leukemia and malignant glioma climbazole receptor [16], [17]. However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related p

• The absorption rate of polyphenols into the body

  2021-08-30

  

  The M871 rate of polyphenols into the body is usually low. For example, the absorption rate of epigallocatechin gallate (EGCG), an active component in GP, is approximately 1% (Chen et al., 1997). To increase absorption of GP in the body, people have been increasing their intake of functional foods

• br Results br Discussion GPCRs recognize

  2021-08-30

  

  Results Discussion GPCRs recognize a broad range of molecules with a vast chemical KL 001 through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids includin

• Among the different factors that modulate Schwann cell biolo

  2021-08-30

  

  Among the different factors that modulate Schwann cell biology, several studies pointed out the role played by neuroactive steroids, in particular progesterone (P4) and its derivatives dihydroprogesterone (DHP) and allopregnanolone (ALLO). Schwann Agarose GPG/ME are steroidogenic, possessing the en

• Each of these substrate receptors belongs to a multigene fam

  2021-08-30

  

  Each of these substrate receptors belongs to a multigene family with tens, if not hundreds of members in plants, and with in part overlapping and in part differential substrate specificities [4]. The complexity of the system is nicely illustrated by the F-box protein and auxin receptor TRANSPORT INH

• br RING type E s

  2021-08-30

  

  RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult

• 2 deoxy d glucose Then we explored the MCLEIA methodology pa

  2021-08-30

  

  Then, we explored the MCLEIA methodology parameters including precision, accuracy and specificity. In the 0.5–128 ng/mL, the standard curve equation was  = 0.5014 + 1.769 ( was log, was RLU/RLU with a correlation coefficient of 0.9907) (). On the one hand, same sample (0.5, 4.0, 32.0 ng/mL) detecte

• Our previous studies have demonstrated that the DDR discoidi

  2021-08-28

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• deoxythymidine receptor The present study provides the first

  2021-08-28

  

  The present study provides the first evidence that the human uroepithelial deoxythymidine receptor in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles

• Behaviors were compared between saline and amphetamine pre

  2021-08-28

  

  Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls

• Flexible alignment of isopropylphenylaminobenzimidazole with

  2021-08-28

  

  Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead Metabolism Compound Library mg 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well a

15777 records 603/1052 page Previous Next First page 上5页 601602603604605 下5页 Last page