• In the present study VTE recurrence occurred in

  2021-11-06

  

  In the present study, VTE recurrence occurred in a non-cancer patient during edoxaban administration, representing recurrence rates of 1.7% in non-cancer patients and 0.8% in all patients. In a sub-analysis of cancer patients [27] and the main analysis [19] in the HOKUSAI-VTE trial, recurrent VTE oc

• The root of Danshen has

  2021-11-06

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• Pharmacological G a inhibition resulted in significant

  2021-11-06

  

  Pharmacological G9a inhibition resulted in significant reduction of viable BTC cells in a concentration- and cell line–dependent manner. Interestingly, we found a significant correlation between BIX01294-IC50 and UNC0642-IC50 values in our BTC cell model—both inhibitors competitively inhibit H3K9 su

• The finding that a peptide consisting of d amino acids

  2021-11-06

  

  The finding that a peptide consisting of d-amino acids binds to LSD1-CoREST1 with equal affinity as the l-amino 9-amino Camptothecin ligand indicates that the assays detect a generally non-specific association between two highly charged molecules. Nonetheless, p53-CTD is an effective inhibitor of L

• br Material and methods br Results

  2021-11-06

  

  Material and methods Results Discussion Liver plays a key role in the metabolism and detoxification of DON (Peng et al., 2017). However, various DON investigations generated inconsistent results, with some showing hepatotoxicity of DON, while others not. For example, one report stated that

• Histamine functions as a key neurotransmitter

  2021-11-05

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, FPH2 is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway (Bor

• Polyunsaturated fatty acids PUFAs represent

  2021-11-05

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic CCT251545 (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic acid (

• br Acknowledgements This work was

  2021-11-05

  

  Acknowledgements This work was supported by the grants from National key Basic Research Program of China (2012CB124702), 948 Program (2015-Z33), National Natural Science Foundation of China (31172093, 31301947), the National Science Foundation for Fostering Talents in Basic Research (J1103510), S

• Neovascularization upon IMQ treatment was

  2021-11-05

  

  Neovascularization upon IMQ treatment was observed to different degrees in WT and GAL3-KO mice, whereas the increase in vascular endothelial growth factor mRNA levels was genotype independent. Because we observed lower levels of the cytokines IL-17A, IL-22, IL-23, and TNF-α in IMQ-treated skin of GA

• br Results and discussion br

  2021-11-05

  

  Results and discussion Conclusion In normal and curd coconuts, full-length cDNA and parental genomic DNA sequences encoding endosperm specific AGal were sequenced and characterized. At least, three mutation rna polymerase ii were identified in CnAGal gene. In vitro expression in K. phaffii sho

• perk kinase br Results and discussion br

  2021-11-05

  

  Results and discussion Conclusion In conclusion, twenty-one 4-monocyclic aryl-5-carbamoyl-3-isoxazolols have been synthesized and evaluated for their antagonistic activities against housefly and common cutworm GABARs expressed in Xenopus oocytes. The TEVC results indicated that perk kinase se

• DAMPs are endogenous danger signals that can

  2021-11-05

  

  DAMPs are endogenous danger signals that can initiate and perpetuate a noninfectious kd025 during cell death [23]. HMGB1 is a well-studied nuclear DAMP in various types of regulated necrosis and has been implicated in the pathogenesis of infection and sterile inflammation. Our current data indicate

• Results of studies on fish FBPase are somewhat confusing

  2021-11-05

  

  Results of studies on fish FBPase are somewhat confusing: although fishes skeletal muscles possess relatively high FBPase activity (Knox et al., 1980, Lushchak et al., 2001) and the isozyme present therein has kinetic properties typical to all vertebrates muscle FBPases (Rosenmann et al., 1977), inv

• Based on pharmacophore modeling a good HDAC inhibitor

  2021-11-04

  

  Based on pharmacophore modeling, a good HDAC inhibitor has at least three sides/regions: the attachment side of the Zn2+ cofactor/HDAC active site (Zn2+ binding group/ZBG), hydrophobic cap (CAP) and linker containing connecting unit (CU) with electronegative groups (Mohan et al., 2011, Rossi et al.,

• On the other hand it is quite

  2021-11-04

  

  On the other hand, it is quite possible that strychnine-sensitive glycine sites are responsible for mediating the anticonvulsant effects of GlyT1 inhibitors. Strychnine, which acts as an antagonist at these sites, is a well-known as a convulsant drug, and elevation of endogenous glycine levels at th

16032 records 580/1069 page Previous Next First page 上5页 576577578579580 下5页 Last page