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Lean mass is representative of the muscle tissue
2022-03-11
Lean mass is representative of the muscle tissue mass equivalent of all the body parts containing water, excluding fat, bone minerals, and such substances which do not contribute to the NMR signal, such as hair, claws, etc. (ECHO-MRI (Houston, TX) user's manual). It was interesting that in the Bob-C
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In the present study we aimed
2022-03-11
In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA enzyme substrate of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs. lean-t
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Thyroid hormone triiodothyronine T and its precursor thyroxi
2022-03-11
Thyroid hormone 3,5,3′-triiodothyronine (T3) and its precursor, thyroxine (T4), are iodinated compounds, which are known to regulate the expression of genes involved in various biological processes, such as development, growth and metabolic control. The iodothyronine deiodinase types I, II and III (
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In the present study recipient oestradiol serum levels on
2022-03-11
In the present study, recipient oestradiol serum levels on the day of donor oocyte retrieval or warming were found to be significantly higher in the antagonist group and higher than 100 pg/ml in all cases. Serum oestradiol level has been reported to have no effect on endometrial receptiveness in ooc
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Acknowledgements This work is partially supported by the Nat
2022-03-11
Acknowledgements This work is partially supported by the Natural Science Foundation of China(81273353), and the National Science & Technology Key Projects of China (2009ZX09103-085). Glyoxalase I (GLO I) is a key enzyme in the pathways leading to glutathione (GSH)-mediated detoxification of meth
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The standard model of stress postulates
2022-03-11
The standard model of stress postulates the activation of both the sympathoadrenomedullary axis and the hypothalamo-pituitary-adrenocortical axis. Long-term activation of either neuroendocrine axes has been shown to be harmful [12]. Short-term activation of the sympathoadrenomedullary axis is used t
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In summary activated A AR exacerbated the reverse transport
2022-03-11
In summary, activated A2AR exacerbated the reverse transport function of endothelial EAATs through a direct or indirect pathway depending on PKA and glutamate levels in response to OGD in vitro, but A2AR inhibition quickly restored the normal transport function. Moreover, the key mechanisms by which
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br Regulation of Glu transporters The pivotal role
2022-03-11
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Lopinavir calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcript
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Glucagon regulates the transition from hepatic glucose utili
2022-03-11
Glucagon regulates the transition from hepatic glucose utilisation in the absorptive state to glucagon production in the post-absorptive state by acute stimulation of glycogenolysis and inhibition of glycolysis [1]. An important component of this response is the phosphorylation of liver PFK2/FBPase2
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br Introduction A great many
2022-03-10
Introduction A great many isoprenoids with varieties of structural diversity, such as steroids, carotenoids, prenyl quinones, and natural rubber, occur in nature. All of these biosynthetic precursors are constructed by the action of prenyl chain elongating enzymes [1], [2], [3], [4]. These enzyme
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br Experimental procedures br Results br Discussion
2022-03-10
Experimental procedures Results Discussion This study demonstrates that the genetic disruption or pharmacological inhibition of FAAH completely prevented all manifestations of pain symptoms in an NTG-induced migraine animal model. Thus, FAAH disruption or blockade abolished the activation o
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Interestingly evidence has emerged recently that suggests
2022-03-10
Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli
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We have expanded these studies by doing
2022-03-10
We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA rifampicin mg or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antago
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br Epigenetic regulation of OA pathogenesis Although epigeno
2022-03-10
Epigenetic regulation of OA pathogenesis Although epigenome of each cell is unique but can undergo temporal and spatial changes in response to environmental stimuli such as diet, exercise, smoking and disease status. Aberrant epigenetic modifications due to environmental factors are associated wi
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Over the last years numerous studies gave insights into sGC
2022-03-10
Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137
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