• Aurora A overexpression is also related to the

  2024-06-26

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer bms webpage [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products and prot

• It was previously demonstrated that dissociation of the V

  2024-06-26

  

  It was previously demonstrated that dissociation of the V-ATPase in response to glucose depletion in yeast requires an intact microtubular network [28] and a catalytically active enzyme [29]. Interestingly, mutations in the non-homologous region of the catalytic subunit A are able to block dissociat

• The presence of crown like structures and inflammatory facto

  2024-06-26

  

  The presence of crown-like structures and inflammatory factors in the breast of obese patients is associated with considerable changes in intracellular signaling and a profound cellular dysfunction. Secreted pro-inflammatory factors can directly promote breast carcinogenesis as they have been report

• Finally the comparison between data obtained by antioxidant

  2024-06-26

  

  Finally, the comparison between data obtained by antioxidant assays in in vitro cultured cells [11], [12] and in liposomes has disclosed the possibility to choose more confidently “the better phenolipid” of a series of fatty acids esters antioxidant derivatives. Looking at the physical parameters th

• Besides above mentioned UV visible and fluorescence spectros

  2024-06-26

  

  Besides above-mentioned UV–visible and fluorescence spectroscopy methods, electron paramagnetic resonance (EPR) spectroscopy, the only analytical method that detect compounds having unpaired electrons known as free radicals, was rarely used in antioxidant capacity measurement (Amarowicz et al., 2004

• Although the gene that encodes DHFR has

  2024-06-26

  

  Although the gene that encodes DHFR has been strongly conserved during evolution, subtle differences in the active sites of bacterial, human and parasite dabigatran etexilate synthesis have been exploited to develop DHFR inhibitors specific to particular pathogens 1, 3. For example, pyrimethamine a

• br Concluding Remarks and Future Perspectives Fluorescent an

  2024-06-26

  

  Concluding Remarks and Future Perspectives Fluorescent Fidaxomicin have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and organisms, and to detect ba

• The sequential behavioral approach used

  2024-06-26

  

  The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t

• Based on the general structure function principle in biology

  2024-06-26

  

  Based on the general structure-function principle in biology [[19], [20], [21]], toxic oligomers are expected to have well-defined three-dimensional structures to carry out their pathological functions. A common amyloid toxicity mechanism also suggests that toxic oligomers of different amyloid prote

• br Conflict of interest br

  2024-06-25

  

  Conflict of interest Introduction Colorectal cancer (CRC) is one of the major cause of tumor-related morbidity and mortality worldwide. Poor prognosis and consequences of its metastatic spread make CRC the second most common cause of cancer-related deaths in western countries [1]. Apart from o

• br Introduction Alcohol i e ethanol is absorbed into

  2024-06-25

  

  Introduction Alcohol, i.e., ethanol, is absorbed into the blood from the stomach to the small intestine, then distributed throughout the body. The metabolism of alcohol converting to acetic cisapride basically involves two enzymes; alcohol dehydrogenase converting ethanol to acetaldehyde and ald

• br Acknowledgments and Disclosures br Introduction

  2024-06-25

  

  Acknowledgments and Disclosures Introduction In mammals, ejaculated sperm requires a finite period of residence in the female reproductive tract to become competent for fertilization (Visconti et al., 1995a, Visconti et al., 1995b). Once oocytes are matured, it is important for these cells to

• Active SI behavior was dose dependently affected by

  2024-06-25

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p affected 6 mercaptopurine mg 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.

• Numerous studies have shown that PUFA incorporation into the

  2024-06-25

  

  Numerous studies have shown that ω-3 PUFA incorporation into the lipid raft can affect the distribution and function of protein in the lipid raft by altering raft composition [25], [26], [27]. For example, DHA treatment excluded phospholipase D (PLD) from lipid raft toward non-lipid raft, resulting

• br Materials and methods br

  2024-06-25

  

  Materials and methods Results and discussions Conclusion Fermented camel milk with NS4 exhibited remarkable ACE-inhibitory activity, which revealed its potential application for the preparation of fermented camel milk beverage or fermented camel milk derived peptides in different foods or i

16129 records 134/1076 page Previous Next First page 上5页 131132133134135 下5页 Last page