• Major outcomes from MADIT II

  2019-05-27

  

  Major outcomes from MADIT-II trial suggested that, once again, the risk of death in defibrillator group was significantly less than conventional-therapy group with hazard ratio of 0.69. In this trial, the major drawback was corrected. The medication use remained balanced between ICD patients, and co

• Examples of numerically generated vortices and their organiz

  2019-05-27

  

  Examples of numerically generated vortices and their organizing centers in 3-D excitable media are illustrated in Fig. 1. Panels a to d show 4 different configurations of 3-D scroll waves that were computed using the FitzHugh–Nagumo model [39,40]. Panel a shows an example of the simplest configurati

• br In December consecutive waves of

  2019-05-24

  

  In December, 2016, consecutive waves of major smog shrouded China, particularly the North China Plain and Sichuan Basin, resulting in suspended schools, halted industrial production, and heavy traffic. Atmospheric levels of fine particulate RG2833 manufacturer (PM) spiked to more than 500 μg/m in

• topoisomerase inhibitors Frustratingly in the past years the

  2019-05-24

  

  Frustratingly, in the past 40 years the world has added only two new drugs to the arsenal against tuberculosis, the second most deadly infectious disease on the planet. The statistics are infuriating: more than 9 million people developed tuberculosis in 2013, and an estimated 44% of those in countri

• Notwithstanding issues of equity improvement of research cap

  2019-05-24

  

  Notwithstanding issues of equity, improvement of research capacity in LMICs has practical benefits. People working and living in LMICs are better placed to define issues of importance to their populations than are people living thousands of miles away in HICs—who often fund research based on their o

• br Acknowledgments We thank all the ultramarathon runners

  2019-05-24

  

  Acknowledgments We thank all the ultramarathon runners who participated in this study and all the doctors, nurses, and emergency medical technicians who provided professional care at the ultramarathon race. We also thank our colleagues at Soochow University, Taipei, Taiwan and the Chinese Taipei

• ICE was introduced as a real

  2019-05-24

  

  ICE was introduced as a real-time imaging technique to assist catheter ablation procedures. Chu et al. performed an ICE-guided catheter ablation in 9 dogs. They concluded that ICE can accurately guide catheter ablation directed at anatomic landmarks. They also used ICE to confirm the endocardial con

• Leptin synthesized in adipocytes is a regulator

  2019-05-24

  

  Leptin, synthesized in adipocytes, is a regulator of fat metabolism and reproduction [7]. The levels of leptin correlate with body fat mass and show a wide variation in individuals. In the bone marrow microenvironment, the leptin secreting adipocytes occupy a significant part [8]. Leptin stimulates

• Case report A previously healthy year old man was

  2019-05-24

  

  Case report A previously healthy 37-year-old man was referred to our hospital in September 2015 with fever (between 37 and 38°C) for 10 days and general malaise. There was no history of recent travel, and the patient had no animals in his home. There were no remarkable features in the heart, lungs,

• br Rheumatic heart disease RHD affects over

  2019-05-24

  

  Rheumatic heart disease (RHD) affects over 32 million people worldwide; the vast majority of patients are in low-income and middle-income countries. It is a leading cause of premature mortality in children and young adults living in endemic regions. Patients with RHD often present in an advanced s

• In contrast median Cu level mg L in

  2019-05-24

  

  In contrast, median Cu level (0.73 mg/L) in our study was approximately 50% lower than that in maternal blood (1.47 mg/L). Our result is consistent with several previously published studies, which showed a 50–60% decrease in Cu level in the fetus. The observed decrease in fetal Cu, a major metallic

• An interesting finding in the study of Ngabo

  2019-05-23

  

  An interesting finding in the study of Ngabo and colleagues was that, after a huge drop in the number of admittances to hospital for rotavirus in 2013, there was no further fall the next year. As the researchers discuss, this finding might herald the beginning of a biennial pattern of rotavirus acti

• It s April and the theme is End

  2019-05-23

  

  It\'s (April 25) and the theme is “End malaria for good”. If I\'m not mistaken, that means eradication. In one of the first Comment pieces ever published, asked “Is it possible? Is it worth it? Should we do it?” and the chemokine receptor antagonist is still divided. Despite remarkable progress i

• In several Western reports from large

  2019-05-23

  

  In several Western reports from large-scale comparative studies and epidemiological surveys, there was no significant difference in the incidence of thromboembolism between paroxysmal and persistent AF patients [46,47]. Data from our institution suggested that the incidence of cardiogenic thromboem

• Su acci n en Chiapas

  2019-05-23

  

  Su acción en Chiapas fracasó, no sólo por el rechazo que generó entre los encomenderos sino también entre los religiosos que apoyaban la encomienda en beneficio propio o bien como mecanismo de cristianización acelerado. Cuando Las Casas regresa po1 Supplier España, en lo que hace a su batalla de ide

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