• In addition to inducing IKs dysfunction through dominant neg

  2019-05-04

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• Por ejemplo se encuentran art culos

  2019-05-04

  

  Por ejemplo, se encuentran artículos que analizan los sistemas curriculares, la didáctica empleada en la enseñanza, la formación de profesores, la pedagogía implementada en las clases, la educación en valores, entre otros. Se destacan varios trabajos que proyectan las reflexiones morinianas en el co

• To more accurately map the

  2019-05-04

  

  To more accurately map the del(7q) and to search for other submicroscopic aberrations, we performed BAC-based array CGH analysis on BM from the accelerated phase. This confirmed an interstitial deletion in chromosome bands 7q22.1-q35 of maximal size 50.0Mb (Fig. 2D). The minimal region of deletion e

• Regarding the pathophysiology of HF with

  2019-04-30

  

  Regarding the pathophysiology of HF with preserved LVEF, AF is one of the most important precipitating factors related to diastolic dysfunction [22,23]. AF might have important roles in the pathogenesis of HF with preserved EF in association with diastolic HF. Compared with JCARE-CARD, which include

• There were differentially expressed genes identified from th

  2019-04-30

  

  There were 3151 differentially expressed genes identified from the transcriptome profiling data of 497 patients (Fig. 2). Among these differentially expressed genes, 2190 genes were found to be upregulated in the group with infiltrating lymphocytes ≥1%. As shown in Table 2, these genes were enriched

• Importa notar al mismo tiempo cierta impaciencia

  2019-04-30

  

  Importa notar, al mismo tiempo, cierta impaciencia con la indeterminación del saber celebrada hasta no hace mucho. En la ruta hacia el neoliberalismo, ese tránsito del Estado al mercado —como suele llamársele en América Latina—, la duda epistémica, el pensamiento débil, los juegos de lenguaje y la r

• A preserva o da ideia de fam lia

  2019-04-30

  

  A preservação da ideia de família tradicional tornou-se uma das principais demandas desses representantes. Neste sentido, o Projeto de Lei n° 6583 de 2011, conhecido como Estatuto da Família, almeja o reconhecimento (pelo Estado) da família como uma entidade formada apenas por um homem, uma mulher e

• Christina Dupl a tambi n procura en su

  2019-04-30

  

  Christina Dupláa también procura en su estudio dar una definición del testimonio, aunque, como sucede con los críticos mencionados hasta el momento, sólo considera el testimonio mediato, dejando oleuropein un lado otras producciones: “El testimonio o discurso-testimonio es un mensaje, la mayoría de

• Rabies has no cure and by the time of clinical

  2019-04-30

  

  Rabies has no cure, and by the time of clinical onset it is invariably fatal. More than 95% of deaths occur in Africa and Asia, 80% of which are in people living in rural, underserved populations, most of whom are children. Community awareness about the power of preventing dog bites and of life-savi

• Notwithstanding issues of equity improvement of research cap

  2019-04-30

  

  Notwithstanding issues of equity, improvement of research capacity in LMICs has practical benefits. People working and living in LMICs are better placed to define issues of importance to their populations than are people living thousands of miles away in HICs—who often fund research based on their o

• Several true lumen re entry devices have

  2019-04-30

  

  Several true lumen re-entry devices have been introduced into the market, including the Outback catheter, allowing fluoroscopically controlled true arterial lumen re-entry after subintimal guidewire passage. A recent retrospective review reported a successful re-entry rate of 91% in 11 patients with

• Sin considerar la poes a de

  2019-04-30

  

  Sin considerar la poesía de Villaurrutia en esta ocasión, es evidente que el pasaje citado representa una elocuente cristalización del su relevancia para el pensamiento y la poética de Octavio Paz. Es notable que el juicio crítico de Paz incluya referencias al universo —donde los opuestos coexisten

• br Conflict of interest br Introduction br Cholangiocytes Ch

  2019-04-30

  

  Conflict of interest Introduction Cholangiocytes Cholangiocytes are epithelial Sulfo-NHS-Biotin cost lining the intra and extrahepatic ducts of the three-dimensional network of the biliary tree. Biliary cells comprise approximately 3–5% of cells in the liver and are considered as one of th

• The goals of Vision the global initiative

  2019-04-30

  

  The goals of Vision 2020—the global initiative to eliminate avoidable blindness by 2020—include increasing cataract surgical rate and cataract surgical coverage. However, quality must not be sacrificed for quantity. The final visual outcome matters, both to the individual patient and to the communit

• Since I created the Doughnut at Oxfam in it

  2019-04-29

  

  Since I created the Doughnut at Oxfam in 2012, it has been widely applied within academia, policymaking, progressive business, urban planning, and civil society as a tool for reconceptualising sustainable development. Here I present a renewed and strengthened framework, based on recent advances in b

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